Salvestrol


Salvestrols cannot be made in the body. They have to be supplied through our diet and to date, herbalists have identified Salvestrols in many organic fruits, vegetables and herbs. It is estimated that our modern diet contains 10 – 20% of the Salvestrols that it did 100 years ago. (Click here to read more about our modern diet)

  • Salvestrols act as a natural rescue mechanism, ensuring our cells function correctly
  • They target diseased cells
  • They are part of our everyday diet and always have been, so they are entirely safe
  • They are not antioxidants
  • They are natural compounds found in fruit, vegetables and herbs
  • They are now grossly deficient in our diet

THE NEED FOR A SALVESTROL SUPPLEMENT

Believing that a simple shift in diet may not have been enough for those fighting an active disease or for those at risk, Professor Potter and Herbalist Anthony Daniels researched the idea of a food supplement.

Through his worldwide contacts, Anthony sourced large volumes of organic fruit and pioneered a unique method of extracting and isolating Salvestrol from the thousands of other compounds.

Due to the success of this extraction, the proprietary brand name “Salvestrol” was born under the company “Natures Defence” making it possible to take Salvestrol as a food supplement in the fight towards better health.


CAN DIET ALONE PROVIDE ALL OUR SALVESTROL NEEDS?

For a number of reasons it is very unlikely to get sufficient intake of Salvestrol from modern foods. Even with a solely organic diet, there is no guarantee of adequate levels, as many modern fruit and vegetable varieties are low in Salvestrol. Differing food-growing locations, food growing methods and whether the food was fully ripe at harvest all have an effect.

Salvestrols are mostly found in the skin, peel or rind of fruit and vegetables and in the modern diet, this is the part of the fruit or vegetable least appealing and often not eaten. Many of the modern varieties of fruit and vegetables have been bred to be less bitter and this has meant that the often bitter salvestrol component has been reduced or removed.


Discovery and Research

The discovery of Salvestrols evolved from the work of research scientist Professor Dan Burke. As a faculty member of Aberdeen University Medical School for nearly 20 years, he specialised in the Cytochrome P450 enzyme system. His research group discovered that an enzyme CYP1B1 was present in diseased cells but absent from healthy tissue.

Burke went on to become head of the School of Pharmacy at De Montfort University, Leicester. At De Montfort he met Professor Gerry Potter, who was Director of the Cancer Drug Discovery Group. When Professor Burke described the CYP enzyme to him, Potter immediately saw the potential of this enzyme in developing therapies for diseased cells.


DISCOVERY IN NATURE

Initially the pair worked on developing synthetic pharmaceutical products to combat disease. But in 2002 they discovered similarly structured compounds were naturally present in many foods. Professor Potter called this new class of natural compounds Salvestrols.


HOW SALVESTROLS WORK IN PLANTS

The best way to picture Salvestrols is to understand their role in the plants that produce them. When attacked by pathogens, primarily fungi plants defend themselves with Salvestrols. Where pathogens contain a CYP enzyme, Salvestrols are metabolised by the enzymes and die.


THE POTENTIAL FOR HUMANS

The CYP1B1 enzyme in diseased cells offers the potential to use the plants’ response and make it part of our own defence. Consuming Salvestrol-rich plants lets Salvestrols enter our diseased cells and induce their death through metabolism by CYP1B1.


SALVESTROL LEVELS IN FOODS

Seeing a leaflet for local Leicester Company, The Herbal Apothecary, led to a meeting between Professor Potter and Managing Director, Anthony Daniels.

The company’s contacts in the global food industry, the herbalist community and organic growers proved enormously important for Professor Potter’s work. Working together, they analysed thousands of fruit, vegetable and herb samples.

It emerged that Salvestrols were present in small amounts or not at all in supermarket produce, while organic samples had Salvestrols in abundance. Meaning the typical western food supply is desperately deficient in Salvestrols.


Are Salvestrols Safe?

Salvestrols are part of our everyday diet and always have been, so they are entirely safe.

Salvestrol is made from organically grown fruit. Mostly they are extracted in high concentrations from tangerine or orange peel and blueberries, and mixed with concentrated blackberry and strawberry powder.


JOURNAL OF ORTHOMOLECULAR MEDICINE - CASE STUDIES

Nutrition and Cancer: Salvestrol case studies - 2007

Schaefer,BA, Hoon LT, Burke DM, Potter GA, (2007) Nutrition and Cancer: Salvestrol case Studies. Journal of Orthomolecular Medicine, 22, 4: 1-6.

Nutrition and Cancer: Further Case Studies Involving Salvestrols - 2010

Schaefer,BA (April 2010) Nutrition and Cancer: Further Case Studies Involving Salvestrol. Journal of Orthomolecular Medicine,25, 1: 17-23

Cancer and Related Case Studies Involving Salvestrols and CYP1B1 - 2012

Link to Case Study: JOM Volume 27, Number 3, 2012

SALVESTROLS: JOURNEYS TO WELLNESS BOOK BY BRIAN SCHAEFER 2013

Salvestrol and Pancreatic Cancer

 


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